Steps of histamine on H1receptors boosts capillary permeability and edema formation, flare and pruritus.Promethazine with Codeine Oral Remedy is not advisable to be used in pregnant Gals [see Use in Certain Populations (eight.1)]. Extended usage of Promethazine with Codeine Oral Remedy during pregnancy may end up in neonatal opioid withdrawal syndr… Read More